CSIR-CIMAP







Analytical Chemistry

Name
: 
Karuna Shanker
Designation
: 
Senior principal scientist
Address
: 
CSIR-CIMAP, Kukrail Picnic Spot Road, PO-CIMAP, Lucknow-226015
E. mail
: 
k.shanker@cimap.res.in
Contact No
: 
09415329718
Fax
: 
580

    Natural product research ¦Analytical & Bio-analytical Chemistry ¦Phytochemistry ¦Pharmacognosy ¦ Standardization and validation of traditional medicines ¦ Chromatographic method development and validation ¦ Validated therapeutic/functional products development ¦ ORCID: https://orcid.org/0000-0003-0144-3623 Scopus: https://www.scopus.com/authid/detail.uri?authorId=14056836200 Mendeley: https://www.mendeley.com/profiles/karuna-shanker2/publications/ PubMed: https://www.ncbi.nlm.nih.gov/pubmed/?term=%22Karuna+Shanker%22 Google Scholar: https://scholar.google.co.in/citations?user=_1MNU5wAAAAJ&hl=en&oi=ao?
  • B.Sc. Physics, Chemistry & Maths
  • Post Doctoral Chemistry (Organic)
  • Ph.D. Chemistry
  • CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, Analytical Chemsitry - Principal Scientist (June 2014- June 2018 )
  • CCRAS-Central Research Institute (Ay.), Lucknow, Drug Standardization Research Unit (DSRU) - Research Officer (Chemistry) (October 1999- June 2004 )
  • Department of Revenue, Ministry of Finance, New Delhi., Central Revenue Control Laboratory (CRCL), - Chemical Assistant-II (September 1997- October 1999 )
  • CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, Analytical Chemsitry - Scientsit-B (June 2004- June 2007 )
  • CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, Analytical Chemsitry - Scientsit-C (June 2007- June 2010 )
  • CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, Analytical Chemsitry - Senior Scientist (June 2010- June 2014 )
  • CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, Analytical Chemsitry - Senior Principal Scientist (June 2018- till date )
  • Gaur, P., Khan, F. and Shanker K*,. Potential lipase inhibitor from underutilized part of Andrographis paniculata: Targeted isolation and mechanism of inhibition..  Industrial Crops and Products, 197, p.116 https://doi.org/10.1016/j.indcrop.2023. 2023
  • Mishra S., Kumar S., Ramdas, Khare S., Shukla A., Shanker K*., Pal A., Khan F., Darokar MP.. Quebrachitol from Putranjiva roxburghii Wall. (Putranjivaceae) a potent antimalarial: Pre-clinical efficacy and its interaction with PfLDH. . Parasitology International https://doi.org/10.1016/j.parint.2022.102675 2023
  • Ranjana,  Binwal M., Verma AK., Bawankule DU., Tiwari N & Shanker K*. Stimulation of glucose uptake by glycosides from Alectra parasitica subsp. chitrakutensis (M.A. Rau) K.K. Khanna & An. Kumar: An in-vitro study of TNF-a induced insulin resistance in L6 myoblasts. . Natural Product Research https://doi.org/10.1080/14786419.2022.2112957 2022
  • Jyotshna, Khare P, Shanker K*. Mangiferin: A review of sources and interventions for biological activities. . BioFactors. 42(5): 504-514. 2016
  • Gaur, P., Tiwari, N. and Shanker, K*. Utilization of Agro-Waste of Piper longum for a Potential Pancreatic Lipase Inhibitor. . ACS Agricultural Science & Technology 2 (3), 580-591 https://doi.org/10.1021/acsagscitech.2c00021 2022
  • Srivastava, M., Maurya, P. and Shanker, K*. Clerodendrum viscosum: a critical review on phytochemistry, pharmacology, quality assurance, and safety data. . Medicinal Chemistry Research, 30(12): pp.2145-2167. 2021
  • Gaur, I., Gaur, P., Gautam, P., Tiwari, N., Khare, P., Tripathi, S. and Shanker K*.. Simplified process of candidate certified reference material development for the analysis of Andrographis paniculata derived therapeutics.  . Microchemical Journal, 165: article ID106140. 2021
  • Srivastava, M. and Shanker, K*. Duranta erecta Linn: A critical review on phytochemistry, traditional uses, pharmacology, and toxicity from phytopharmaceutical perspective. . Journal of Ethnopharmacology, 293, p. Article ID.115274. https://doi.org/10.1016/j.jep.2022.115274 2022
  • Srivastava N, Mishra S, Iqbal H, Chanda D, Shanker K*. Standardization of Kaempferia galanga L. rhizome and vasorelaxation effect of its key metabolite ethyl p-methoxycinnamate. . Journal of Ethnopharmacology, 271: Article ID 113911. https://doi.org/10.1016/j.jep.2021.113911 2021
  • Mishra S, Kumar S, Darokar MP, Shanker K* . Novel bioactive compound from the bark of Putranjiva roxburghii Wall. . Natural Product Research, 35(10): 1738-1740. https://doi.org/10.1080/14786419.2019.1633650 2021
  • Mishra S., Singh S., Ali A., Gupta AC., Shanker K* . Microwave-assisted single step cinnamic acid derivatization and evaluation for cytotoxic potential. . Current Pharmaceutical Biotechnology, 21(3): 236-243. https://doi.org/10.2174/1389201020666191015161429 2020
  • Jyotshna, Gupta AC, Bawankule DU, Verma AK, and Shanker K*. Nanoemulsion preconcentrate of a pentacyclic triterpene for improved oral efficacy: Formulation design and in-vivo antimalarial activity. . Journal of Drug Delivery Science and Technology, 57: Article ID 101734. https://doi.org/10.1016/j.jddst.2020.101734 2020
  • Dixit, S., Maurya, P., Srivastava, M., Shanker, K*., Bawankule, DU., Gupta, MM., Rai, LK. Quantitation of dietary dihydrochalcones in Indian crabapple (Malus sikkimensis) using validated high-performance liquid chromatography. . Journal of Chromatographic Science, 57(8): 679-687. https://doi.org/10.1093/chromsci/bmz040 2019
  • Srivastava, N., Singh, S., Gupta, A. C., Shanker K*., Bawankule, D. U., Luqman, S.. Aromatic ginger (Kaempferia galanga L.) extracts with ameliorative and protective potential as a functional food, beyond its flavor and nutritional benefits. . Toxicology Reports, 6: 521-528. 2019
  • Mishra, S., Srivastava, N., Sundaresan, V., Shanker K*. Amruthapala (Decalepis arayalpathra (J. Joseph and V. Chandras.) Venter): A Comprehensive Review on Diversity, Therapeutic Uses, and Valorization of Bioactive Constituents. . Current Pharmaceutical Biotechnology. 20(5): 376-389. 2019
  • Yadav KS, Tandon S, Yadav NP, Shanker K*. Pharmacokinetic study of hepatoprotective coumarinolignoids from Cleome viscosa in mice using validated high-performance liquid chromatography-photodiode array method. . Pharmacognosy Magazine, 15(61): 270-276. 2019
  • Srivastava, M., Maurya, P., Mishra, S., Kumar, N., Shanker K*.. Chemotaxonomic differentiation of Clerodendrum species based on high-performance thin-layer chromatographic fingerprinting of key secondary metabolites and chemometric data analysis. . JPC-Journal of Planar Chromatography-Modern TLC, 32(3): 211-222. 2019
  • Singh, M., Mohan, R., Mishra, S., Goyal, N., Shanker K.*Gupta, N., Kumar, B. . Ultra performance liquid chromatography coupled with principal component and cluster analysis of Swertia chirayita for adulteration check. . Journal of Pharmaceutical and Biomedical Analysis,164: 302-308. 2019
  • Srivastava, M., Singh, M., Maurya, P., Srivastava, N., Gupta, N., Shanker, K*. . Simultaneous quantification of five bioactive phenylethanoid, iridoid, and flavonol glycosides in Duranta erecta L.: Ultra performance liquid chromatography method validation and uncertainty measurement. . Journal of Pharmaceutical and Biomedical Analysis, 174: 711-717. 2019
  • Ranjana, Nooreen, Z., Bushra, U., Bawankule, D.U., Shanker K,* Ahmad, A. and Tandon, S.,. Standardization and xanthine oxidase inhibitory potential of Zanthoxylum armatum fruits. . Journal of Ethnopharmacology, 230:1-238. 2019
  • Maurya, P., Singh, M., Srivastava, M. and Shanker K* . Development and validation of UPLC-PDA method for quality control of dikamali gum-a natural tablet binder: Fast simultaneous quantitation of six polymethoxyflavones. . Chromatographia, 81(9): 1277-1285 2018
  • Maurya, P., Srivastava, M. and Shanker K*. Simultaneous quantification of six polymethoxyflavones in Gardenia lucida Roxb. using high-performance thin-layer chromatography. . JPC-Journal of Planar Chromatography-Modern TLC, 31(4): 309-317. 2018
  • Jyotshna, Srivastava Nupur, Yadav AK, Shanker K*, Gupta MM, Lal RK.. Impact of postharvest processes on major phenolic constituents and antioxidant potentials of different Ocimum species.. Journal of Applied Research on Medicinal and Aromatic Plants,10: 9-15. 2018
  • Jyotshna, Gaur, P.; Singh, D. K.; Luqman, S.; Shanker K*.. Validated method for quality assessment of henna (Lawsonia inermis L.) leaves after postharvest blanching and its cosmetic application. . Industrial Crops and Products, 95: 33-42 2017
  • Shanker K*, Khare P, Tiwari N, Mohanty S, U Bawankule D, Pal A.. Synthesis of gold mediated biocompatible nanocomposite of lactone enriched fraction from Sahadevi (Vernoniacinerea Lees): An assessment of antimalarial potential. . Current Topics in Medicinal Chemistry, 16(18): 2043-2050. 2016
  • Jyotshna, Srivastava N, Singh B, Chanda D, and Shanker K* . Chemical composition and acetylcholinesterase inhibitory activity of Artemisia maderaspatana essential oil. . Pharmaceutical Biology, 53(11):1677-1683. 2015
  • Srivastava P, Jyotshna, Debabrata C, Shanker K* . Chemical characterization and acetylcholinesterase inhibition potential of volatile components of aerial parts of Pluchea lanceolate ( DC.) Oliv. & Hiern. . Records of Natural Products, 9(4): 586-591. 2015
  • Jyotshna, Srivastava P, Killadi B, and Shanker K* . Uni-dimensional double development HPTLC-densitometry method for simultaneous analysis of mangiferin and lupeol content in mango (Mangifera indica) pulp and peel during storage.. Food Chemistry,176: 91-98. 2015
  • Srivastava P, Ajayakumar PV, and Shanker K*. Box–Behnken design for optimum extraction of biogenetic chemicals from P. lanceolata with an energy audit (Thermal?×?Microwave?×?Acoustic): A case study of HPTLC determination with additional specificity using on-line/off-line coupling with DAD/NIR/ESI-MS. . Phytochemical Analysis, 25(6): 551-560. 2014
  • Srivastava P, Jyotshna, Gupta N, Maurya AK, and Shanker K* . New anti-inflammatory triterpene from the root of Ricinus communis. . Natural Product Research, 28(5): 306-311 2014
  • Srivastava P, Mohanty S, Bawankule DU, Khan F, Shanker K* . Effect of Pluchea lanceolata bioactives in LPS-induced neuroinflammation in C6 rat glial cells. . Naunyn-Schmiedeberg's Archives of Pharmacology, 387(2): 119-127. 2014
  • Srivastava P., Maurya US., Pal A., Bawankule DU., Shanker K* . Enrichment of aglycone fractions with immunomodulatory potential: Stability and pharmacokinetic of Withania bioactives. . Food Research International, 54(1): 867-872. 2013
  • Chanda D, Pal A and Shanker K* . Application of HPLC fingerprints for defining in-vivo safety profile of Tulsi (Ocimum Sanctum). . Medicinal Chemistry Research, 22(1) 219-224. 2013
  • Srivastava P., and Shanker K*. Pluchea lanceolata (Rasana): Chemical and biological potential of Rasayana herb used in traditional system of medicine. . Fitoterapia, 83(8): 371-1385. 2012
  • Singh R., Trivedi P., Bawankule DU., Ahmad A.,Shanker K* . HILIC quantification of Oenotheralanosterol A and B from Oenothera biennis and their suppression of IL-6 and TNF-a expression in mouse macrophages.. Journal of Ethnopharmacology, 141: 357-362. 2012
  • Singh S., Singh R., Banerjee S.,Negi AS.,Shanker K*. Determination of anti-tubercular agent in mango ginger (Curcuma amada Roxb.) by reverse phase HPLC-PDA-MS. . Food Chemistry, 131(1): 375-379. 2012
  • Trivedi P.,Singh R., & Shanker K*. Micellar extraction and cloud-point preconcentration of labdane diterpenoids from Andrographis paniculata. . Journal of Liquid Chromatography and Related Technologies, 34(18): 2085-2102. 2011
  • Trivedi P., Kumar JK., Negi AS., Shanker K* . HPLC method development and validation of cytotoxic agent phenylheptatriyne in Bidens pilosa with ultrasonic assisted cloud point extraction and preconcentration. . Biomedical chromatography, 25: 697-706. 2011
  • Karuna Shanker*, Madan M. Gupta, Santosh K. Srivastava, Dnyaneshwar U. Bawankule, Anirban Pal and Suman PS Khanuja. Determination of bioactive nitrile glycoside(s) in drumstick (Moringa oleifera) by reverse phase HPLC.. Food Chemistry ,105: 376–382. 2007
  • Shanker K*.,Fatima A., Negi AS., Gupta VK., Darokar MP., Gupta MM., Khanuja SPS.. RP-HPLC method for quantitation of Yashti-madhu (Glycyrrhiza glabra). . Chromatographia, 65: 771-774. 2007

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