Name : Shivprasad Suresh Patil Designation : Scientist-C Address : CSIR-CIMAP (Lucknow) E. mail : sspatil[dot]cimap[at]csir[dot]res[dot]in Contact No : 7807193846 Epabx No. : 0 Download Resume Area of Specialization Our research group employs a multidisciplinary approach at the interface of chemistry and biology to decipher the molecular insights of life and decode complex pharmacological mechanisms. By synergizing methodologies from Phytochemistry, (Bio)Analytical Chemistry, Plant Extracellular Vesicle Biochemistry, Sustainable Solvents (Natural Deep Eutectic Solvents), and Biological Mass Spectrometry (Proteomics, Metabolomics, and Lipidomics), supported by integrated in silico, in vitro, and in vivo models, we drive innovation in therapeutics development. Core Research Domains: Theme 1: Plant Extracellular Vesicles (PEVs): Next-Generation Natural Nanomedicine Platform Exploitation of plant-derived extracellular vesicles for targeted drug delivery, biomolecular cargo profiling, and nanomedicine applications. Theme 2: Smart NADES and THEDES - Design and application of Smart Natural Deep Eutectic Solvents (Smart NADES) and Therapeutic Deep Eutectic Solvents (THEDES) for sustainable extraction, stabilization, and enhanced delivery of bioactive molecules. Theme 3: AI-enabled Bioactivity-Guided Discovery Platform for Next Generation Botanical Drugs - Develop an integrated AI platform that predicts active phytochemicals before purification. Theme 4: Deciphering the Disease Mechanism and biomarkers - A Mass Spectrometry-based approach to understand the molecular events of disease by exploring MHC-peptidome, sub-cellular organelles, and Extracellular Vesicles to identify specific therapeutic targets and clinical biomarkers. For more information, please visit our group page: https://sites.google.com/view/shivpatilresearchgroup/home (copy and paste the link) Education B.Sc. Biochemistry M.Sc. Biochemistry Ph.D. Biological Sciences Academic/Research Experience CSIR-IHBT, Palampur-Himachal pradesh, Chemical Technology - Postdoctoral Researcher (February 2022- January 2023 ) The University of North Carolina, NC-USA, Centre for Biomedical Translational Research - Postdoctoral Researcher (January 2023- January 2026 ) CSIR-CIMAP, Lucknow, Phytochemistry - Scientist C (June 2026- till date ) Honours and Awards Junior Research Fellowship,PhDby CSIR in 2017-2022 Publication Patil, S. S., & Zhang, Q. Impact of preanalytical factors on plasma extracellular vesicles and human plasma proteome.. Clinical Proteomics 2026 Patil, S.S. & Ruchika. Advances in Phytomolecules Isolation: Green Extraction and High-Resolution Separation. RSC-Natural Product Reports 2026 Patil, S. S., & Zhang, Q. Comprehensive Comparison of Methods for Isolation of Extracellular Vesicles from Human Plasma.. Journal of Proteome Research 2025 Patil, S. S., Sun, X., Zhou, Z., & Zhang, Q.. Spatial Proteomics Reveals Alcohol-Induced Damages to the Crypts and Villi of the Mouse Small Intestine. Journal of Proteome Research 2024 Patil, S. S., Anmol, & Sharma, U.. Implementing sustainable methods in natural products research.. Trends in Chemistry 2024 Patil, S. S., Kumari, S., Sahal, D., & Sharma, U.. Innate functions of natural products: a promising path for identification of novel therapeutics.. European Journal of Medicinal Chemistry 2023 Patil, S. S., Singh, P. P., Sharma, M., & Sharma, U.. Multicomponent natural deep eutectic solvents: Super solvents for the efficient extraction of steviol glycosides (rebaudioside A) from Stevia rebaudiana. . Journal of Cleaner Production 2023 Patil, S. S., Kesarwani, V., Kumari, S., Shankar, R., & Sharma, U.. Bisbenzylisoquinolines from Cissampelos pareira L. as antimalarial agents: Molecular docking, pharmacokinetics analysis, and molecular dynamic simulation studies. . Computational Biology and Chemistry 2023 Patil, S. S., Thakur, K. G., & Sharma, U. . Molecular docking and dynamic simulation approach to decipher steroidal sapogenins (genus Trillium) derived agonists for glucocorticoid receptor. . Journal of Biomolecular Structure and Dynamics 2023 Patil, S.S., Kesarwani, V., Kumari, S., Shankar, R., & Sharma, U. Flavonoids from Aerial Parts of Cissampelos pareira L. as Antimalarial Agents: Computational Validation of Ethnopharmacological Relevance. South African Journal of Botany 2023 Patil, S.S., Singh, P.P., Sharma, A., Padwad, Y.S., & Sharma, U. . Steroidal saponins of Trillium govanianum: quality control, pharmacokinetic analysis, and anti-inflammatory activity. Biocatalysis and Agricultural Biotechnology 2021 Patil, S.S., Singh, P.P., Padwad, Y.S., & Sharma, U. . Steroidal saponins from Trillium govanianum as a-amylase, a-glucosidase, and dipeptidyl peptidase IV inhibitory agents. Journal of Pharmacy and Pharmacology 2021 Patents File No Title Inventors Patent No. Abstract