Name : Dr. Kapil Dev Designation : Senior Scientist Address : CSIR-CIMAP, Near Kukrail Picnic Spot, Lucknow-226015, India E. mail : kapildev[at]cimap[dot]res[dot]in Contact No : 9450816954 Epabx No. : 538 Download Resume Area of Specialization Natural Product Chemistry, Medicinal Chemistry, For more information please visit: https://sites.google.com/view/kapilslab/home Education B.Sc. Chemistry, Physics, Mathematics M.Sc. Pharmaceutical Chemistry Ph.D. Chemical Sciences Academic/Research Experience CSIR-Central Drug Research Institute, Lucknow, India , - Project Assistant-II (March 2010- July 2012 ) CSIR-Central Drug Research Institute, Lucknow, India , - CSIR-Junior Research Fellow (July 2012- July 2014 ) CSIR-Central Drug Research Institute, Lucknow, India, - CSIR-Senior Research Fellow (July 2014- January 2017 ) Jubilant Chemsys Pvt. Ltd., Noida, India, - Research Scientist-II (March 2017- February 2019 ) Yunnan University, Kunming, China, - Postdoctoral Research Fellow (March 2019- November 2019 ) CSIR-CIMAP, Lucknow, - Scientist (November 2019- till date ) Honours and Awards Best Poster Award,by HNBGU, Dehradun, India in 2012 Technology Award,by CSIR-CDRI, Lucknow in 2019 Incentive Award,by CSIR-CDRI, Lucknow in 2020 Publication Srivastava, S.; Mishra, D.; Bisht, R.; Savita, K.; Singh, K.; Rani, P.; Chanda, D.; Dev, K.*. Psiguanol, a novel a-pyrone derivative from Psidium guajava leaves and vasorelaxant activity in rat aorta cells through intracellular cGMP-dependent opening of calcium-activated potassium channels. Natural Products Research 2024 Mugale, M. N.; Dev K.; More, B. S.; Mishra, S. V.; Washimkar, R. Kaveri.; Singh, K.; Maurya, R.; Rath, S. K.; Chattopadhyay, D.; Chattopadhyay, N.. A comprehensive review on preclinical safety and toxicity of medicinal plants. Clinical Complementary Medicine and Pharmacology 2024 Maurya, P.; Dwivedi, N.; Mazeed, A.; Kumar, D.; Kumar, B.; Channotiya, C. S.; Dev, K., Suryavanshi, P.. Allelopathic weed management in wheat (Triticum aestivum L.) through essential oil emulsions and aqueous botanical extracts based novel bioherbicides.. Journal of Plant Diseases and Protection 2024 Gupta, R. K.; Singh, S.; Chanotiya, C. S.; Dev, K.; Trivedi, P. K.; Singh, A.. Diversity and functional characterization of endophytes in two contrasting cultivars of Ocimum sanctum: Insights from culture-based and metagenomic approaches. Journal of Plant Growth Regulation 2024 Singh, K.; Yadav, A.; Khan, S.; Shukla, A.; Alam, M.; Verma, A. K.; Tiwari, N.; Khan, F.; Yadav, P. N.; Dev, K.*. Baicalein isolated from Oroxylum indicum acts as a potent µ- and ?-opioid receptor antagonist agent via the reversal of agonist-mediated cAMP inhibition. Natural Product Research 2024 Akansha Mishra, Khushbu Sharma, Jyotsana Pandey, Kapil Dev, Sleman Kadan, Mahendra Sahai, Ishbal Ahmad, Arvind K. Srivastava, Akhilesh K. Tamrakar, Hilal Zaid, Rakesh Maurya. Tinosporaside from Tinospora cordifolia Encourages Skeletal Muscle Glucose Transport through Both PI-3-Kinase- and AMPK-Dependent Mechanisms. Molecules 28(2), 483, 2023 Kapil Dev, Shraddha Srivastava, Rohit Bisht. Chemical and Pharmacological Profile of Psidium guajava: A Mini Review. Indian Forester Journal, 148 (4), 245-255, 2022 Dev, K.; Srivastava, S.; Bisht, R. . Chemical and Pharmacological Profile of Psidium guajava: A Mini Review. Indian Forester Journal 2022 Pandey, J.; Dev, K.; Chattopadhyay, S.; Kadan, S.; Sharma, T.; Sanyal, S.; Siddiqi, M. I.; Zaid, I.; & Tamrakar, A.. ß-Sitosterol-D-Glucopyranoside Mimics Estrogenic Properties and Stimulates Glucose Utilization in Skeletal Muscle Cells. Molecules 2021 Trivedi, R.; Adhikary, S.; Kothari, P.; Ahmad, N.; Mittapelly, N.; Pandey, G.; Shukla, M.; Kumar, S.; Dev, K.; Choudhary, D.; Maurya, R.; Lal, J.; Mishra, P. R.,. Self-emulsifying formulation of Spinacia oleracea reduces the dose and escalates bioavailability of bioactive compounds to accelerate fracture repair in rats. Clinical Phytoscience 2020 Singh, A.; Singh, P.; Kumar, B.; Kumar, S.; Dev, K.; Maurya, R.,. Detection of flavonoids from Spinacia oleracea leaves using HPLC-ESI-QTOF-MS/MS and UPLCQqQLIT-MS/MS techniques. Natural Products Research 2018 Choudhary, D.; Kothari, P.; Tripathi, A. K.; Singh, S.; Adhikary, S.; Ahmad, N.; Kumar, S.; Dev, K.; Mishra, V. K.; Shukla, S.; Maurya, R.; Mishra, P. R.; Trivedi, R.,. Spinacia oleracea extract attenuates disease progression and sub-chondral bone changes in monosodium iodoacetate induced osteoarthritis in rats. BMC Complementary and Alternative Medicine 2018 Maurya S. W.; Dev, K.; Prakash, R.; John, A. A.; Siddiqui, I. R.; Singh, D.; Maurya, R., . Design and synthesis of indolyl chalcone analogues and evaluation of their osteogenic activity. Journal of Pharmacology and Pharmaceutical Research 2018 Gautam Brahmachari, Kapil Dev; E. Ramakrishna; Rakesh Maurya;. Glucose Transporter 4 (GLUT4) Translocation Activators from Nature. Discovery and Development of Anti-Diabetic Agents from Natural Products: Natural Product Drug Discovery, Elsevier, ISBN: 978-0-128-09692-5, 2016, Chapter 4, pp 113-145 2017 Prof. Gautam Brahmachari; Kapil Dev; Rakesh Maurya;. Marine-Derived Anti-Alzheimer’s Agents of Promise. Neuroprotective Natural Products: Clinical Aspects and Mode of Action Wiley-VCH, ISBN: 978-3-527-34186-3, 2017, Chapter 7, pp 153-184 2017 Dev, K.; Ramakrishna, E.; Kothari, P.; Tripathi, A. K.; Trivedi, R. and Maurya, R.. Phytochemical investigation of Kigelia pinnata leaves and identification of osteogenic agents. Medicinal Chemistry Research, 2017, 26, 940-940 2017 Singh, K. B.; Dixit, M.; Dev, K.; Rakesh Maurya; and Divya Singh.. Formononetin, a methoxy isoflavone, enhances bone regeneration in a mouse model of cortical bone defect.. British Journal of Nutrition, 117, 1511-1522 2017 Dev, K.; Ramakrishna, E.; Maurya, S. W.; Siddiqui, I. R.; Kant, R. and Maurya, R.. Ugi three-component reaction of alcohols, amines and isocyanides: A new approach to the synthesis of cyclic amidines. Tetrahedron Letters , 58, 1202-1206, 2017 Dev, K.; Ramakrishna, E.; Maurya, S. W.; Siddiqui, I. R. and Maurya, R.. Hypervalent iodine (III)-mediated oxidation of aryl sulfonylhydrazones: A facile synthesis of N-aroyl-N'-acyl arylsulfonylhydrazides. Tetrahedron Letters, 58, 570-573, 2017 Maurya, S. W.; Dev, K.; Singh, K. B.; Rai, R.; Siddiqui, I. R.; Singh, D.; Maurya, R.. Synthesis and biological evaluation of heterocyclic analogues of pregnenolone as novel anti-osteoporotic agents. Bioorganic & Medicinal Chemistry Letters 27, 1390-1396, 2017 Porwal, K.; Pal, S.; Dev, K.; China, S. P.; Kumar, Y.; Singh, C.; Barbhuyan, T.; Sinha, N.; Sanyal, S.; Trivedi, A. K.; Maurya, R. and Chattopadhyay, N.. Guava fruit extract and its triterpene constituents have osteoanabolic effect: stimulation of osteoblast differentiation by activation of mitochondrial respiration via the Wnt/ß-catenin signalling. The Journal of Nutritional Biochemistry 44, 22-34, 2017 Adhikary, S.; Choudhary, D.; Ahmad, N.; Kumar, S.; Dev, K.; Mittapelly, N.; Pandey, G.; Mishra, P. R.; Maurya, R.; Trivedi, R.,. Dried and free flowing granules of Spinacia oleracea accelerate bone regeneration and alleviate post-menopausal osteoporosis. Menopause, 24, 686-698, 2017 Gautam, J.; Khedgikar, V.; Kushwaha, P.; Choudhary, D.; Nagar, G. K.; Dev, K.; Dixit, P.; Singh, D.; Maurya, R.; Trivedi, R.. Formononetin, an isoflavone, activates AMPK/ß-catenin signaling to inhibit adipogenesis and rescues C57BL/6 mice against high fat diet induced obesity and bone loss. British Journal of Nutrition, 117, 645-661, 2017 Srivastava, A.; Singh, H.; Mishra, R.; Dev, K.; Tandon, P.; Maurya, R.,. Structural insights, protein-ligand interactions and spectroscopic characterization of isoformononetin. Journal of Molecular Structure 1133, 479-491, 2017 Singh, H.; Singh, S.; Srivastava, A.; Tandon, P.; Bharti, P.; Kumar, S.; Dev, K.; Maurya, R.. Study of hydrogen?bonding, vibrational dynamics and structure-activity relationship of genistein using spectroscopic techniques coupled with DFT. Journal of Molecular Structure 1133, 929-939, 2017 Mittal, M.; Pal, S.; China, S. P.; Porwal, K.; Dev, K.; Shrivastava, R.; Raju, K. S.; Rashid, M.; Trivedi, A. K.; Sanyal, S.; Wahajuddin, M.; Bhaduria, S.; Maurya, R.; Chattopadhyay, N.. Pharmacological activation of aldehyde dehydrogenase 2 promotes osteoblast differentiation via bone morphogenetic protein-2 and induces bone anabolic effect. Toxicology and Applied Pharmacology 316, 63-73, 2017 Mansoori, M. N.; Tyagi, A. M.; Shukla, P.; Srivastava, K.; Dev, K.; Chillara, R.; Maurya, R.; Singh, D.. Methoxy isoflavone formononetin and isoformononetin inhibit the differentiation of Th17 cells and B-cell lymphopoesis to promote osteogenesis in estrogen-deficient bone loss conditions. Menopause 23, 565-576, 2016 Srivastava, A.; Mishra, R.; Kumar, S.; Dev, K.; Tandon, P.; Maurya, R.. Molecular structure, spectral investigation (1H NMR, 13C NMR, UV–Visible, FT-IR, FT-Raman), NBO, intramolecular hydrogen bonding, chemical reactivity and first hyperpolarizability analysis of formononetin [7-hydroxy-3(4-methoxyphenyl)chromone]: A quantum chemical study. Journal of Molecular Structure 1084, 55-73, 2015 Taneja, I.; Raju, K. S. R.; Mittal, M.; Dev, K.; Khan, M. F.; Maurya, R.; Wahajuddin, M.. Bioavailability, plasma protein binding and metabolic stability studies of ALDH2 activator, alda-1, using validated LC-ESI-MS/MS method in rat plasma. RSC Advances 5, 54395-54402, 2015 Dev, K. and Maurya, R.. Facile synthesis of 11-aryl-6H-isoindolo[2,1-a]-indol-6-ones via hypervalent iodine(III)-promoted cascade cyclization.. RSC Advances 5, 13102-13106, 2015 Khan, M. F.; Maurya, C. K.; Dev, K.; Arha, D.; Rai, A. K.; Tamrakar, A. K. and Maurya, R.. Design and synthesis of lupeol analogues and their glucose uptake stimulatory effect in L6 skeletal muscle cells.. Bioorganic & Medicinal Chemistry Letters 24, 2674-2679, 2014 Omeje, E. O.; Khan, M. P.; Osadebe, P. O.; Tewari, D.; Khan, M. F.; Dev, K.; Maurya, R. and Chattopadhyay, N.. Analysis of constituents of the eastern Nigeria mistletoe, Loranthus micranthus Linn revealed presence of new classes of osteogenic compounds.. Journal of Ethnopharmacology 151, 643–651, 2014 Dev, K.; Khan, M. F.; Lahiri, S.; Dixit, M.; Trivedi, R.; Singh, D. and Maurya, R.. Osteogenic activity of natural diterpenoids isolated from Cupressus sempervirens fruits in calvarial derived osteoblast cells via differentiation and mineralization.. Phytomedicine 21, 1794–1800, 2014 Dev, K.; Khan, M. F.; Lahiri, S.; Dixit, M.; Trivedi, R.; Singh, D. and Maurya, R.. Osteogenic activity of natural diterpenoids isolated from Cupressus sempervirens fruits in calvarial derived osteoblast cells via differentiation and mineralization.. Phytomedicine 21, 1794–1800, 2014 Yadav, D. K.; Singh, N.; Dev, K.; Sharma, R.; Sahai, M.; Palit, G. and Maurya, R.. Anti-ulcer constituents of Annona squamosa twigs.. Fitoterapia 82, 666-675, 2011 Patents File No Title Inventors Patent No. Abstract 10265297 Formulation for the prevention and treatment of bone related disorders Ritu Trivedi; Prabhat R. Mishra; Sulekha Adhikari; Naseer Ahmad; Dharmendra Chaudhary; Naresh Mittapally; Sudhir Kumar; Kapil Dev; Rakesh Maurya United States/10265297/23-04-2019 00:00:00 The present invention relates to a formulation of Spinacea oleracea useful for the prevention or treatment of osteo-health related disorders. The present invention relates to the field of pharmaceutical formulation that provides extract, fractions, pure compound isolated from natural sources and formulation thereof useful for the prevention and treatment of various medical indications. Further, this invention relates to conditions associated with estrogen dependent or independent diseases (primary/secondary osteoporosis) or syndromes or disorders preferably relating to cartilage such as osteoarthritis caused in humans and animals. Furthermore, this invention relates to achievement of peak bone mass during skeletal growth and health in humans and animals. Particularly, the present invention relates to the processes for the preparation of biologically active extracts, from Spinacea oleracea from the family Amaranthaceae their pharmaceutically acceptable excipients and compositions of the principal aspect of the present invention. 20180000776 Pharmaceutical composition for the prevention and/or treatment of bone related disorders Ritu Trivedi; Prabhat R. Mishra; Sulekha Adhikari; Naseer Ahmad; Dharmendra Chaudhary; Naresh Mittapally; Sudhir Kumar; Kapil Dev; Rakesh Maurya India/20180000776 /08-05-2023 00:00:00 The present invention relates to a formulation of Spinacea oleracea useful for the prevention or treatment of osteo-health related disorders. The present invention relates to the field of pharmaceutical formulation that provides extract, fractions, pure compound isolated from natural sources and formulation thereof useful for the prevention and treatment of various medical indications. Further, this invention relates to conditions associated with estrogen dependent or independent diseases (primary/secondary osteoporosis) or syndromes or disorders preferably relating to cartilage such as osteoarthritis caused in humans and animals. Furthermore, this invention relates to achievement of peak bone mass during skeletal growth and health in humans and animals. Particularly, the present invention relates to the processes for the preparation of biologically active extracts, from Spinacea oleracea from the family Amaranthaceae their pharmaceutically acceptable excipients and compositions of the principal aspect of the present invention.